Selective binding of Trypanosoma cruzi to host cell membrane polypeptides
نویسندگان
چکیده
منابع مشابه
Trypanosoma cruzi–Host Cell Interaction
Chagas disease was discovered by Carlos Chagas in Brazil in 1909 (1). It is caused by the pathogenic protozoan Trypanosoma cruzi, member of Trypanosomatidae family, Kinetoplastida order. Chagas disease is recognized by the World Health Organization as one of the main neglected tropical diseases, affecting about 8–15 million individuals in 18 countries in Central and South America, where it is e...
متن کاملReview on Trypanosoma cruzi: Host Cell Interaction
Trypanosoma cruzi, the causative agent of Chagas' disease, which affects a large number of individuals in Central and South America, is transmitted to vertebrate hosts by blood-sucking insects. This protozoan is an obligate intracellular parasite. The infective forms of the parasite are metacyclic and bloodstream trypomastigote and amastigote. Metacyclic trypomastigotes are released with the fe...
متن کاملInternalization of components of the host cell plasma membrane during infection by Trypanosoma cruzi.
Epimastigote and trypomastigote forms of Trypanosoma cruzi attach to the macrophage surface and are internalized with the formation of a membrane bounded vacuole, known as the parasitophorous vacuole (PV). In order to determine if components of the host cell membrane are internalized during formation of the PV we labeled the macrophage surface with fluorescent probes for proteins, lipids and si...
متن کاملMolecular analysis of early host cell infection by Trypanosoma cruzi.
Trypanosoma cruzi, the causative agent of Chagas heart disease, infects heart and other cells leading to cardiac arrest frequently followed by death. The disease affects millions of individuals in the Americas and is posing health problems because of blood transmission in the US due to large Latin American immigration. Since the current drugs present serious side effects and do not cure the chr...
متن کاملMembrane traffic and synaptic cross-talk during host cell entry by Trypanosoma cruzi
It is widely accepted that Trypanosoma cruzi can exploit the natural exocytic response of the host to cell damage, utilizing host cell lysosomes as important effectors. It is, though, increasingly clear that the parasite also exploits endocytic mechanisms which allow for incorporation of plasma membrane into the parasitophorous vacuole. Further, that these endocytic mechanisms are involved in c...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1990
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.58.1.1-6.1990